Unknown

Dataset Information

0

High Serum Iron level is Associated with Increased Mortality in Patients with Sepsis.

ABSTRACT: Iron is an essential nutrient for bacterial survival and thus higher iron levels may precipitate bacterial infections. We investigated the association between the serum iron level and prognosis in patients with sepsis by using the single-centre Medical Information Mart for Intensive Care III (MIMIC-III) database. Sepsis patients with iron parameters measured on ICU admission were included and stratified according to quartiles of serum iron levels. A total of 1,891 patients diagnosed with sepsis according to the Sepsis-3 criteria were included in this study, 324 of whom were septic shock. After adjusting for confounding variables, higher iron quartile was associated with an increase in 90-day mortality in the Cox regression analysis. Moreover, a stepwise increase in the risk of 90-day mortality was observed as the quartiles of serum iron levels increased in the patients with sepsis. In conclusion, higher serum iron levels were independently associated with increased 90-day mortality in this large cohort of patients with sepsis.

SUBMITTER: Lan P 

PROVIDER: S-EPMC6056487 | biostudies-other | 2018 Jul

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

High Serum Iron level is Associated with Increased Mortality in Patients with Sepsis.

Lan Peng P   Pan Kong-Han KH   Wang Shuo-Jia SJ   Shi Qiu-Cheng QC   Yu Yun-Xian YX   Fu Ying Y   Chen Yan Y   Jiang Yan Y   Hua Xiao-Ting XT   Zhou Jian-Cang JC   Yu Yun-Song YS  

Scientific reports 20180723 1

Iron is an essential nutrient for bacterial survival and thus higher iron levels may precipitate bacterial infections. We investigated the association between the serum iron level and prognosis in patients with sepsis by using the single-centre Medical Information Mart for Intensive Care III (MIMIC-III) database. Sepsis patients with iron parameters measured on ICU admission were included and stratified according to quartiles of serum iron levels. A total of 1,891 patients diagnosed with sepsis  ...[more]

Similar Datasets

Unknown Increased serum thrombomodulin level is associated with disease severity and mortality in pediatric sepsis.
| S-EPMC5542536 | biostudies-other
Unknown An increased chloride level in hypochloremia is associated with decreased mortality in patients with severe sepsis or septic shock.
| S-EPMC5698440 | biostudies-literature
Unknown Soluble TREM-1 Serum Level can Early Predict Mortality of Patients with Sepsis, Severe Sepsis and Septic Shock.
| S-EPMC6061141 | biostudies-literature
Unknown Sepsis-Induced Coagulopathy Phenotype Induced by Oxidized High-Density Lipoprotein Associated with Increased Mortality in Septic-Shock Patients.
| S-EPMC10045333 | biostudies-literature
Unknown Does an increase in serum FGF21 level predict 28-day mortality of critical patients with sepsis and ARDS?
| S-EPMC8216835 | biostudies-literature
Unknown Serial evaluation of the serum lactate level with the SOFA score to predict mortality in patients with sepsis.
| S-EPMC10113181 | biostudies-literature
Unknown Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients.
| S-EPMC8746736 | biostudies-literature
Unknown Increased serum resistin level is associated with coronary heart disease.
| S-EPMC5564838 | biostudies-other
Unknown Abnormal serum chloride is associated with increased mortality among unselected cardiac intensive care unit patients.
| S-EPMC8075550 | biostudies-literature
Unknown Abnormal Serum Sodium is Associated With Increased Mortality Among Unselected Cardiac Intensive Care Unit Patients.
| S-EPMC7033827 | biostudies-literature