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Endothelial dysfunction in patients with granulomatosis with polyangiitis: a case-control study.

ABSTRACT: BACKGROUND:Granulomatosis with polyangiitis (GPA) is a rare granulomatous vasculitis affecting small- and medium-sized blood vessels. In optimally treated patients with long-standing disease, the common cause of death is atherosclerosis even in the absence of typical risk factors. OBJECTIVE:To evaluate endothelial dysfunction in GPA patients. METHODS:44 patients (21 men and 23 women) diagnosed with GPA and 53 controls matched for age, sex, BMI and typical risk factors for cardiovascular diseases (22 men and 31 women) were enrolled in the study. We measured each participant's serum levels of vascular cell adhesion molecule-1 (VCAM-1), interleukin 6 (IL-6), and thrombomodulin. We also studied flow-mediated dilatation (FMD) of the brachial artery, intima-media thickness (IMT) of the common carotid artery and aortic stiffness using echocardiography. RESULTS:Patients with GPA showed a 15.9% increase in serum levels of VCAM-1 (p?=?0.01), 66% of IL-6 (p?

SUBMITTER: Pacholczak R 

PROVIDER: S-EPMC6060787 | biostudies-other | 2018 Aug

REPOSITORIES: biostudies-other

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Endothelial dysfunction in patients with granulomatosis with polyangiitis: a case-control study.

Pacholczak Renata R   Bazan-Socha Stanisława S   Iwaniec Teresa T   Zaręba Lech L   Kielczewski Stan S   Walocha Jerzy A JA   Musiał Jacek J   Dropiński Jerzy J  

Rheumatology international 20180530 8

<h4>Background</h4>Granulomatosis with polyangiitis (GPA) is a rare granulomatous vasculitis affecting small- and medium-sized blood vessels. In optimally treated patients with long-standing disease, the common cause of death is atherosclerosis even in the absence of typical risk factors.<h4>Objective</h4>To evaluate endothelial dysfunction in GPA patients.<h4>Methods</h4>44 patients (21 men and 23 women) diagnosed with GPA and 53 controls matched for age, sex, BMI and typical risk factors for c  ...[more]

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