Dataset Information

Interplay between spinal cord and cerebral cortex metabolism in amyotrophic lateral sclerosis.

ABSTRACT: We recently reported the potential of Hough transform in delineating spinal cord metabolism by 18F-fluorodeoxyglucose PET/CT scanning in amyotrophic lateral sclerosis. The present study aimed to verify the relationship between spinal cord and brain metabolism in 44 prospectively recruited patients affected by amyotrophic lateral sclerosis submitted to 18F-fluorodeoxyglucose brain and whole-body PET/CT. Patients were studied to highlight the presence of brain hypo- or hypermetabolism with respect to healthy controls, and multiple regression analysis was performed to evaluate the correlation between spinal cord and brain metabolism. Our results confirmed higher 18F-fluorodeoxyglucose uptake in both cervical and dorsal spinal cord in patients with amyotrophic lateral sclerosis with respect to controls. This finding was paralleled by the opposite pattern in the brain cortex that showed a generalized reduction in tracer uptake. This hypometabolism was particularly evident in wide regions of the frontal-dorsolateral cortex while it did not involve the midbrain. Bulbar and spinal disease onset was associated with similar degree of metabolic activation in the spinal cord. However, among spinal onset patients, upper limb presentation was associated with a more pronounced metabolic activation of cervical segment. Obtained data suggest a differential neuro-pathological state or temporal sequence in disease progression.

SUBMITTER: Marini C

PROVIDER: S-EPMC6061793 | biostudies-other | 2018 Aug

REPOSITORIES: biostudies-other

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Interplay between spinal cord and cerebral cortex metabolism in amyotrophic lateral sclerosis.

Marini Cecilia C Morbelli Silvia S Cistaro Angelina A Campi Cristina C Caponnetto Claudia C Bauckneht Matteo M Bellini Alessandro A Buschiazzo Ambra A Calamia Iolanda I Beltrametti Mauro C MC Margotti Simone S Fania Piercarlo P Poggi Ilaria I Cabona Corrado C Capitanio Selene S Piva Roberta R Calvo Andrea A Moglia Cristina C Canosa Antonio A Massone AnnaMaria A Nobili Flavio F Mancardi Gianluigi G Chiò Adriano A Piana Michele M Sambuceti Gianmario G

Brain : a journal of neurology 20180801 8

We recently reported the potential of Hough transform in delineating spinal cord metabolism by 18F-fluorodeoxyglucose PET/CT scanning in amyotrophic lateral sclerosis. The present study aimed to verify the relationship between spinal cord and brain metabolism in 44 prospectively recruited patients affected by amyotrophic lateral sclerosis submitted to 18F-fluorodeoxyglucose brain and whole-body PET/CT. Patients were studied to highlight the presence of brain hypo- or hypermetabolism with respect ...[more]

PMID: 30730551

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Dataset Information

Interplay between spinal cord and cerebral cortex metabolism in amyotrophic lateral sclerosis.

Publications

Interplay between spinal cord and cerebral cortex metabolism in amyotrophic lateral sclerosis.

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