Ontology highlight
ABSTRACT:
SUBMITTER: Kim HJ
PROVIDER: S-EPMC6061841 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Kim Hye Ji HJ Shin Jihoon J Lee Sangho S Kim Tae Wan TW Jang Hyonchol H Suh Min Young MY Kim Jae-Hwan JH Hwang In-Young IY Hwang Deog Su DS Cho Eun-Jung EJ Youn Hong-Duk HD
Nucleic acids research 20180701 13
Cyclin-dependent kinase 1 (Cdk1) is indispensable for embryonic stem cell (ESC) maintenance and embryo development. Even though some reports have described a connection between Cdk1 and Oct4, there is no evidence that Cdk1 activity is directly linked to the ESC pluripotency transcription program. We recently reported that Aurkb/PP1-mediated Oct4 resetting is important to cell cycle maintenance and pluripotency in mouse ESCs (mESCs). In this study, we show that Cdk1 is an upstream regulator of th ...[more]