Ontology highlight
ABSTRACT:
SUBMITTER: Coutinho FP
PROVIDER: S-EPMC6062516 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Coutinho Frazer P FP Green Colin R CR Rupenthal Ilva D ID
Scientific reports 20180726 1
The current study investigated the use of two cationic peptides, Xentry-KALA (XK) and Xentry-Protamine (XP), for intracellular delivery of Connexin43 antisense oligonucleotides (Cx43AsODN). The charge and size of Cx43AsODN:XK and Cx43AsODN:XP complexes was determined by Zetasizer analysis. The earliest positive zeta potential reading was obtained at a 1:2 and 1:1.2 charge ratio of Cx43AsODN:XK and Cx43AsODN:XP respectively, with Cx43AsODN:XK resulting in overall larger complexes than Cx43AsODN:X ...[more]