The Prosigna gene expression assay and responsiveness to adjuvant cyclophosphamide-based chemotherapy in premenopausal high-risk patients with breast cancer.
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ABSTRACT:
SUBMITTER: Jensen MB
PROVIDER: S-EPMC6062869 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Publications
The Prosigna gene expression assay and responsiveness to adjuvant cyclophosphamide-based chemotherapy in premenopausal high-risk patients with breast cancer.
Jensen Maj-Britt MB Lænkholm Anne-Vibeke AV Nielsen Torsten O TO Eriksen Jens Ole JO Wehn Pernille P Hood Tressa T Ram Namratha N Buckingham Wesley W Ferree Sean S Ejlertsen Bent B
Breast cancer research : BCR 20180727 1
<h4>Background</h4>The PAM50-based (Prosigna) risk of recurrence (ROR) score and intrinsic subtypes are prognostic for women with high-risk breast cancer. We investigate the predictive ability of Prosigna regarding the effectiveness of cyclophosphamide-based adjuvant chemotherapy in premenopausal patients with high-risk breast cancer.<h4>Methods</h4>Prosigna assays were performed on the NanoString platform in tumors from participants in Danish Breast Cancer Group (DBCG) 77B, a four-arm trial tha ...[more]
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