Ontology highlight
ABSTRACT:
SUBMITTER: Suma M
PROVIDER: S-EPMC6071599 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Suma Michiko M Kitagawa Teppei T Nakase Yukiko Y Nakazawa Norihiko N Yanagida Mitsuhiro M Matsumoto Tomohiro T
G3 (Bethesda, Md.) 20180731 8
The centromere is a chromosomal locus where a microtubule attachment site, termed kinetochore, is assembled in mitosis. In most eukaryotes, with the exception of holocentric species, each chromosome contains a single distinct centromere. A chromosome with an additional centromere undergoes successive rounds of anaphase bridge formation and breakage, or triggers a cell cycle arrest imposed by DNA damage and replication checkpoints. We report here a study in <i>Schizosaccharomyces pombe</i> to cha ...[more]