Ontology highlight
ABSTRACT:
SUBMITTER: Santos CCF
PROVIDER: S-EPMC6071832 | biostudies-other | 2017 Apr
REPOSITORIES: biostudies-other
Santos Carla C F CCF Paradela Luciana S LS Novaes Luiz F T LFT Dias Sandra M G SMG Pastre Julio C JC
MedChemComm 20161125 4
This work describes the total synthesis of the alkaloid cenocladamide and a concise library of nine structural analogues aiming at their evaluation against the breast cancer cell line MDA-MB-231. The most promising compound (<b>3</b>; IC<sub>50</sub> = 6.6 μM) was also evaluated in a panel of seven breast cancer cell lines and two non-tumorigenic cell lines. We further conducted an initial investigation on the mechanism of action of analogue <b>3</b>, which lacks the endocyclic double bond when ...[more]