Ontology highlight
ABSTRACT:
SUBMITTER: Urbini M
PROVIDER: S-EPMC6073125 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Urbini Milena M Indio Valentina V Astolfi Annalisa A Tarantino Giuseppe G Renne Salvatore Lorenzo SL Pilotti Silvana S Dei Tos Angelo Paolo AP Maestro Roberta R Collini Paola P Nannini Margherita M Saponara Maristella M Murrone Ludovica L Dagrada Gian Paolo GP Colombo Chiara C Gronchi Alessandro A Pession Andrea A Casali Paolo Giovanni PG Stacchiotti Silvia S Pantaleo Maria Abbondanza MA
International journal of molecular sciences 20180623 7
Extraskeletal myxoid chondrosarcoma (EMC) is an extremely rare soft tissue sarcoma, marked by a translocation involving the <i>NR4A3</i> gene. EMC is usually indolent and moderately sensitive to anthracycline-based chemotherapy. Recently, we reported on the therapeutic activity of sunitinib in a series of EMC cases, however the molecular target of sunitinib in EMC is unknown. Moreover, there is still the need to identify alternative therapeutic strategies. To better characterize this disease, we ...[more]