Ontology highlight
ABSTRACT:
SUBMITTER: Cazzaniga A
PROVIDER: S-EPMC6073190 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Cazzaniga Alessandra A Locatelli Laura L Castiglioni Sara S Maier Jeanette J
International journal of molecular sciences 20180621 7
Vascular endothelial growth factor (VEGF) is important for maintaining healthy endothelium, which is crucial for vascular integrity. In this paper, we show that VEGF stimulates the nuclear translocation of endothelial differentiation-related factor 1 (EDF1), a highly conserved intracellular protein implicated in molecular events that are pivotal to endothelial function. In the nucleus, EDF1 serves as a transcriptional coactivator of peroxisome proliferator-activated receptor gamma (PPARγ), which ...[more]