Unknown

Dataset Information

0

Treatment outcomes and HIV drug resistance of patients switching to second-line regimens after long-term first-line antiretroviral therapy: An observational cohort study.


ABSTRACT: To investigate the responses to switching to second-line regimens among patients who had received a long-term first-line antiretroviral therapy.Patients switching to second-line regimens from June 2008 to June 2015 were enrolled from an observational cohort. In addition, patients continuing first-line therapy and had a viral load <1000?copies/mL were included as controls in July 2012. All these patients were followed-up for 36 months or until June 2016. The virological, immunological outcomes, and drug resistance were evaluated. Virological failure was defined as viral load ?1000?copies/mL after 6 months of treatment since the start of the study.There were 304 patients switching to second-line regimens and 46 patients remaining on first-line therapy enrolled while having received first-line therapy for a median of 7.6 years. Patients with plasma viral load (VL) ?1000?copies/mL before switching to second-line regimens had a sharp decline in the proportion of virological failure with 26.7%, 20.4%, and 17.0% at 12, 24, and 36 months after regimen switch, respectively (trend test, P?

SUBMITTER: Cao P 

PROVIDER: S-EPMC6076136 | biostudies-other | 2018 Jul

REPOSITORIES: biostudies-other

altmetric image

Publications

Treatment outcomes and HIV drug resistance of patients switching to second-line regimens after long-term first-line antiretroviral therapy: An observational cohort study.

Cao Pi P   Su Bin B   Wu Jianjun J   Wang Zhe Z   Yan Jiangzhou J   Song Chang C   Ruan Yuhua Y   Xing Hui H   Shao Yiming Y   Liao Lingjie L  

Medicine 20180701 28


To investigate the responses to switching to second-line regimens among patients who had received a long-term first-line antiretroviral therapy.Patients switching to second-line regimens from June 2008 to June 2015 were enrolled from an observational cohort. In addition, patients continuing first-line therapy and had a viral load <1000 copies/mL were included as controls in July 2012. All these patients were followed-up for 36 months or until June 2016. The virological, immunological outcomes, a  ...[more]

Similar Datasets

| S-EPMC8661077 | biostudies-literature
| S-EPMC9013990 | biostudies-literature
| S-EPMC3694021 | biostudies-literature
| S-EPMC7160415 | biostudies-literature
| S-EPMC6340053 | biostudies-literature
| S-EPMC3581035 | biostudies-literature
| S-EPMC3840925 | biostudies-literature
| S-EPMC7093820 | biostudies-literature
| S-EPMC4597210 | biostudies-literature
| S-EPMC4502989 | biostudies-literature