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CX3CR1+ Macrophages and CD8+ T Cells Control Intestinal IgA Production.

ABSTRACT: Secretory IgA is a key host defense mechanism that controls the intestinal microbiota. We investigated the role of CD11c+CX3CR1+CD64+ macrophages in IgA production in the intestine. Intestinal CX3CR1+ macrophages directly induced IgA secretion by B cells. Ag delivery to lamina propria (LP) CX3CR1+ macrophages specifically induced intestinal IgA production. The induction of IgA by CX3CR1+ macrophages required BAFF, a proliferation-inducing ligand, and TNF-α, but was surprisingly independent of TLR-mediated microbial recognition and retinoic acid signaling. IgA secretion by CX3CR1+ macrophages was enhanced by LP CD8+ T cells through the secretion of IL-9 and IL-13. CX3CR1+ macrophages and CD8+ T cells induced IgA production by B cells independently of mesenteric lymph nodes and Peyer patches. Our data reveal a previously unrecognized cellular circuitry in which LP CX3CR1+ macrophages, B cells, and CD8+ T cells coordinate the protective Ig secretion in the small intestine upon peripheral Ag delivery.

SUBMITTER: Kim YI 

PROVIDER: S-EPMC6082403 | biostudies-other | 2018 Aug

REPOSITORIES: biostudies-other

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CX<sub>3</sub>CR1<sup>+</sup> Macrophages and CD8<sup>+</sup> T Cells Control Intestinal IgA Production.

Kim Young-In YI   Song Joo-Hye JH   Ko Hyun-Jeong HJ   Kweon Mi-Na MN   Kang Chang-Yuil CY   Reinecker Hans-Christian HC   Chang Sun-Young SY  

Journal of immunology (Baltimore, Md. : 1950) 20180709 4

Secretory IgA is a key host defense mechanism that controls the intestinal microbiota. We investigated the role of CD11c<sup>+</sup>CX<sub>3</sub>CR1<sup>+</sup>CD64<sup>+</sup> macrophages in IgA production in the intestine. Intestinal CX<sub>3</sub>CR1<sup>+</sup> macrophages directly induced IgA secretion by B cells. Ag delivery to lamina propria (LP) CX<sub>3</sub>CR1<sup>+</sup> macrophages specifically induced intestinal IgA production. The induction of IgA by CX<sub>3</sub>CR1<sup>+</sup>  ...[more]

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