Ontology highlight
ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC6086830 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Nature communications 20180810 1
Glaucoma is the most prevalent neurodegenerative disease and a leading cause of blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not fully understood. Here we show, using mice deficient in T and/or B cells and adoptive cell transfer, that transient elevation of intraocular pressure (IOP) is sufficient to induce T-cell infiltration into the retina. This T-cell infiltration leads to a prolonged phase of retinal ganglion cell degeneration that persists after IOP return ...[more]