SRCP1 Conveys Resistance to Polyglutamine Aggregation.
Ontology highlight
ABSTRACT:
SUBMITTER: Santarriaga S
PROVIDER: S-EPMC6091221 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Publications
SRCP1 Conveys Resistance to Polyglutamine Aggregation.
Santarriaga Stephanie S Haver Holly N HN Kanack Adam J AJ Fikejs Alicia S AS Sison Samantha L SL Egner John M JM Bostrom Jonathan R JR Seminary Emily R ER Hill R Blake RB Link Brian A BA Ebert Allison D AD Scaglione K Matthew KM
Molecular cell 20180701 2
The polyglutamine (polyQ) diseases are a group of nine neurodegenerative diseases caused by the expansion of a polyQ tract that results in protein aggregation. Unlike other model organisms, Dictyostelium discoideum is a proteostatic outlier, naturally encoding long polyQ tracts yet resistant to polyQ aggregation. Here we identify serine-rich chaperone protein 1 (SRCP1) as a molecular chaperone that is necessary and sufficient to suppress polyQ aggregation. SRCP1 inhibits aggregation of polyQ-exp ...[more]
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