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Unexpected good outcome in severe cerebral fat embolism syndrome.


ABSTRACT: In this case study, we report the longitudinal and multimodal follow-up of a catastrophic initial presentation of cerebral fat embolism syndrome. We show that despite the initial severity, the cognitive outcome was ultimately very good but with a highly nonlinear time-course and prolonged loss of consciousness (more than 2 months). Repeated clinical assessments and brain-imaging techniques (electroencephalography, event-related potential, 18-Fluoro-Deoxy-Glucose-PET and magnetic resonance imaging) allowed us to monitor and anticipate this dynamic, providing relevant information to guide decision making in front of withdrawal of life-sustaining therapy discussions. This case illustrates the value of multimodal functional imaging in devastating brain injuries.

SUBMITTER: Hermann B 

PROVIDER: S-EPMC6093841 | biostudies-other | 2018 Aug

REPOSITORIES: biostudies-other

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Unexpected good outcome in severe cerebral fat embolism syndrome.

Hermann Bertrand B   Brisson Hélène H   Langeron Olivier O   Pyatigorskaya Nadya N   Paquereau Julie J   Robert Hélène H   Stender Johan J   Habert Marie-Odile MO   Naccache Lionel L   Monsel Antoine A  

Annals of clinical and translational neurology 20180705 8


In this case study, we report the longitudinal and multimodal follow-up of a catastrophic initial presentation of cerebral fat embolism syndrome. We show that despite the initial severity, the cognitive outcome was ultimately very good but with a highly nonlinear time-course and prolonged loss of consciousness (more than 2 months). Repeated clinical assessments and brain-imaging techniques (electroencephalography, event-related potential, <sup>18</sup>-Fluoro-Deoxy-Glucose-PET and magnetic reson  ...[more]

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