Ontology highlight
ABSTRACT:
SUBMITTER: Shepherd SD
PROVIDER: S-EPMC6093872 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Shepherd Sarah D SD O'Buckley Sandra C SC Harrington James M JM Haines Laura G LG Rothrock Ginger D GD Johnson Leah M LM Nackley Andrea G AG
Scientific reports 20180815 1
A moldable and biodegradable dental material was designed for customized placement and sustained delivery of bupivacaine (BP) within an extraction cavity. Microparticles comprising poly(lactic-co-glycolic acid) (PLGA) containing BP were generated via solvent-evaporation and combined with absorbable hemostat Gelfoam®. Kinetics of drug release were evaluated by in vitro dialysis assays, showing higher release within the first 24 hours, with subsequent tapering of release kinetics. Formulations of ...[more]