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A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain.


ABSTRACT: A moldable and biodegradable dental material was designed for customized placement and sustained delivery of bupivacaine (BP) within an extraction cavity. Microparticles comprising poly(lactic-co-glycolic acid) (PLGA) containing BP were generated via solvent-evaporation and combined with absorbable hemostat Gelfoam®. Kinetics of drug release were evaluated by in vitro dialysis assays, showing higher release within the first 24?hours, with subsequent tapering of release kinetics. Formulations of Gelfoam® and BP-PLGA microparticles (GelBP), with three targeted dosing profiles (0.25, 0.5, and 1?mg/kg/day), were evaluated alongside acute subcutaneous BP injections (2?mg/kg) to determine analgesic efficacy in a rat model of tooth extraction pain. Molar extraction resulted in mechanical and thermal cold hyperalgesia in male and female rats. GelBP outperformed acute BP in blocking post-surgical dental pain, with the 0.25?mg/kg GelBP dose preventing hypersensitivity to mechanical (p?

SUBMITTER: Shepherd SD 

PROVIDER: S-EPMC6093872 | biostudies-other | 2018 Aug

REPOSITORIES: biostudies-other

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A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain.

Shepherd Sarah D SD   O'Buckley Sandra C SC   Harrington James M JM   Haines Laura G LG   Rothrock Ginger D GD   Johnson Leah M LM   Nackley Andrea G AG  

Scientific reports 20180815 1


A moldable and biodegradable dental material was designed for customized placement and sustained delivery of bupivacaine (BP) within an extraction cavity. Microparticles comprising poly(lactic-co-glycolic acid) (PLGA) containing BP were generated via solvent-evaporation and combined with absorbable hemostat Gelfoam®. Kinetics of drug release were evaluated by in vitro dialysis assays, showing higher release within the first 24 hours, with subsequent tapering of release kinetics. Formulations of  ...[more]

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