Ontology highlight
ABSTRACT:
SUBMITTER: He L
PROVIDER: S-EPMC6093888 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Experimental & molecular medicine 20180814 8
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. 5-Fluorouracil (5-FU) is widely used in the treatment of cancers, but its antineoplastic activity is limited in drug-resistant cancer cells. To investigate the detailed mechanism of 5-FU resistance, we developed a model of 5-FU-resistant cells from HCT-8 cells, a well-established colorectal cancer cell line. We found that the drug-resistant cells demonstrated high expression of TCF4 and β-catenin, indicating ...[more]