Cortical Reorganization of Sensorimotor Systems and the Role of Intracortical Circuits After Spinal Cord Injury.
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ABSTRACT:
SUBMITTER: Mohammed H
PROVIDER: S-EPMC6095783 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Publications
Cortical Reorganization of Sensorimotor Systems and the Role of Intracortical Circuits After Spinal Cord Injury.
Mohammed Hisham H Hollis Edmund R ER
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20180701 3
The plasticity of sensorimotor systems in mammals underlies the capacity for motor learning as well as the ability to relearn following injury. Spinal cord injury, which both deprives afferent input and interrupts efferent output, results in a disruption of cortical somatotopy. While changes in corticospinal axons proximal to the lesion are proposed to support the reorganization of cortical motor maps after spinal cord injury, intracortical horizontal connections are also likely to be critical s ...[more]
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