Ontology highlight
ABSTRACT:
SUBMITTER: Hung JH
PROVIDER: S-EPMC6095880 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Hung Jung-Hsien JH Li Chung-Hsien CH Yeh Ching-Hua CH Huang Pin-Cheng PC Fang Cheng-Chieh CC Chen Yen-Fu YF Lee Kuo-Jui KJ Chou Chih-Hung CH Cheng Hsin-Yun HY Huang Hsien-Da HD Chen Marcelo M Tsai Ting-Fen TF Lin Anya Maan-Yuh AM Yen Chia-Hung CH Tsou Ann-Ping AP Tyan Yu-Chang YC Chen Yi-Ming Arthur YA
Scientific reports 20180816 1
Glycine N-methyltransferase (GNMT) is a tumor suppressor for HCC. It is down-regulated in HCC, but the mechanism is not fully understood. MicroRNA-224 (miR-224) acts as an onco-miR in HCC. This study is the first to investigate miR-224 targeting the coding region of GNMT transcript. The GNMT-MT plasmid containing a miR-224 binding site silent mutation of the GNMT coding sequence can escape the suppression of miR-224 in HEK293T cells. Expression of both exogenous and endogenous GNMT was suppresse ...[more]