Ontology highlight
ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC6096887 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Sun Yameng Y Zhang Ting T Zhang Yan Y Li Jinfeng J Jin Lei L Sun Yinyi Y Shi Nan N Liu Kangyong K Sun Xiaojiang X
Neurochemical research 20180725 9
This study aimed to investigate whether ischemic postconditioning (IpostC) alleviates cerebral ischemia/reperfusion (I/R) injury involved in autophagy. Adult Sprague-Dawley rats were divided into five groups: sham (sham surgery), I/R (middle cerebral artery occlusion [MCAO] for 100 min, then reperfusion), IpostC (MCAO for 100 min, reperfusion for 10 min, MCAO for 10 min, then reperfusion), IpostC+3MA (3-methyladenine, an autophagy inhibitor, administered 30 min before first reperfusion), and Ipo ...[more]