Ontology highlight
ABSTRACT:
SUBMITTER: Touchard C
PROVIDER: S-EPMC6098833 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Critical care (London, England) 20180819 1
<h4>Background</h4>Amikacin infusion requires targeting a peak serum concentration (C<sub>max</sub>) 8-10 times the minimal inhibitory concentration, corresponding to a C<sub>max</sub> of 60-80 mg/L for the least susceptible bacteria to theoretically prevent therapeutic failure. Because drug pharmacokinetics on extracorporeal membrane oxygenation (ECMO) are challenging, we undertook this study to assess the frequency of insufficient amikacin C<sub>max</sub> in critically ill patients on ECMO and ...[more]