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Predictors of insufficient peak amikacin concentration in critically ill patients on extracorporeal membrane oxygenation.

ABSTRACT: Amikacin infusion requires targeting a peak serum concentration (Cmax) 8-10 times the minimal inhibitory concentration, corresponding to a Cmax of 60-80 mg/L for the least susceptible bacteria to theoretically prevent therapeutic failure. Because drug pharmacokinetics on extracorporeal membrane oxygenation (ECMO) are challenging, we undertook this study to assess the frequency of insufficient amikacin Cmax in critically ill patients on ECMO and to identify relative risk factors.This was a prospective, observational, monocentric study in a university hospital. Patients on ECMO who received an amikacin loading dose for suspected Gram-negative infections were included. The amikacin loading dose of 25 mg/kg total body weight was administered intravenously and Cmax was measured 30 min after the end of the infusion. Independent predicators of Cmax?

SUBMITTER: Touchard C 

PROVIDER: S-EPMC6098833 | biostudies-other | 2018 Aug

REPOSITORIES: biostudies-other

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Predictors of insufficient peak amikacin concentration in critically ill patients on extracorporeal membrane oxygenation.

Touchard Cyril C   Aubry Alexandra A   Eloy Philippine P   Bréchot Nicolas N   Lebreton Guillaume G   Franchineau Guillaume G   Besset Sebastien S   Hékimian Guillaume G   Nieszkowska Ania A   Leprince Pascal P   Luyt Charles-Edouard CE   Combes Alain A   Schmidt Matthieu M  

Critical care (London, England) 20180819 1

<h4>Background</h4>Amikacin infusion requires targeting a peak serum concentration (C<sub>max</sub>) 8-10 times the minimal inhibitory concentration, corresponding to a C<sub>max</sub> of 60-80 mg/L for the least susceptible bacteria to theoretically prevent therapeutic failure. Because drug pharmacokinetics on extracorporeal membrane oxygenation (ECMO) are challenging, we undertook this study to assess the frequency of insufficient amikacin C<sub>max</sub> in critically ill patients on ECMO and  ...[more]