Ontology highlight
ABSTRACT:
SUBMITTER: Vignal N
PROVIDER: S-EPMC6099542 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Vignal Nicolas N Cisternino Salvatore S Rizzo-Padoin Nathalie N San Carine C Hontonnou Fortune F Gelé Thibaut T Declèves Xavier X Sarda-Mantel Laure L Hosten Benoît B
Molecules (Basel, Switzerland) 20180607 6
[<sup>18</sup>F]FEPPA is a specific ligand for the translocator protein of 18 kDa (TSPO) used as a positron emission tomography (PET) biomarker for glial activation and neuroinflammation. [<sup>18</sup>F]FEPPA radiosynthesis was optimized to assess in a mouse model the cerebral inflammation induced by an intraperitoneal injection of <i>Salmonella enterica</i> serovar <i>Typhimurium</i> lipopolysaccharides (LPS; 5 mg/kg) 24 h before PET imaging. [<sup>18</sup>F]FEPPA was synthesized by nucleophil ...[more]