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The dental infections in patients undergoing preoperative dental examination before surgical treatment of saccular intracranial aneurysm.

ABSTRACT: Dental bacterial DNA and bacterial-driven inflammation markers have previously been detected in intracranial aneurysm tissue samples. This study aimed (i) to assess the possible presence of dental infectious foci, (ii) and the possible association between typical odontogenic bacteria and clinical dental findings in patients undergoing pre-operative dental examination before surgical treatment of saccular intracranial aneurysm. Ninety patients with an intracranial aneurysm were recruited to the study, and the patients' teeth were routinely investigated. Clinical data and bacterial samples from the gingival pockets were collected from a subpopulation of 60 patients. Five typical dental pathogens and total bacteria amounts were measured from gingival samples using real-time quantitative PCR.The amounts of total bacterial and Fusobacterium nucleatum DNA were significantly higher in the patients with ??6 mm gingival pockets than patients without them (p?

SUBMITTER: Pyysalo MJ

PROVIDER: S-EPMC6102815 | biostudies-other | 2018 Aug

REPOSITORIES: biostudies-other

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The dental infections in patients undergoing preoperative dental examination before surgical treatment of saccular intracranial aneurysm.

Pyysalo Mikko J MJ Pyysalo Liisa M LM Hiltunen Jenni J Järnstedt Jorma J Helminen Mika M Karhunen Pekka J PJ Pessi Tanja T

BMC research notes 20180820 1

<h4>Objective</h4>Dental bacterial DNA and bacterial-driven inflammation markers have previously been detected in intracranial aneurysm tissue samples. This study aimed (i) to assess the possible presence of dental infectious foci, (ii) and the possible association between typical odontogenic bacteria and clinical dental findings in patients undergoing pre-operative dental examination before surgical treatment of saccular intracranial aneurysm. Ninety patients with an intracranial aneurysm were ...[more]

PMID: 30126459

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Project description:BACKGROUND:Surgical site infections (SSI) are rare but severe complications after total joint arthroplasty (TJA). Decolonization measures prior to elective orthopedic surgeries have shown to reduce the risk of SSI with Staphylococcus aureus (S. aureus). OBJECTIVE:To determine the efficacy of universal decolonization with Polyhexanide on SSI rates with a focus on Staphylococcus aureus in patients with TJA. METHODS:Patients scheduled for elective hip or knee TJA in 5 participating certified orthopedic centers were included between 2015 and 2018 into this before and after study. Data on patients, surgeries and infections were prospectively collected. CDC-criteria were used to define and categorize Infections within 90?days after surgery. From January 2017 on, patients received decolonization sets containing Polyhexanide. Patients performed a 5?day decolonization regimen starting 4?days prior to surgery which included wipes, nasal decontamination and oral solution. RESULTS:Thirteen thousand, three hundred fifteen patients received TJA. During intervention 4437 decolonization sets were distributed among 7175 patients. Overall SSI rates increased from 0.68 /100 surgeries to 0.91/ 100 surgeries after implementation of the intervention (IRR 1.32; 95% CI 0.90-1.96). Time series analysis identified an increasing trend of SSI prior to the intervention. After implementation overall SSI rates plateaued. Regression analysis revealed surgery during intervention period to be an independent risk factor for developing a SSI (OR 1.34; 95%CI 1.18-1.53). Initial SSI rates due to S. aureus were 0.24/100 surgeries and decreased to 0.14/100 surgeries (IRR 0.57; 95% CI 0.25-1.22) after introduction of decolonization. Regression analysis revealed surgery during intervention period to be an independent protective factor for developing a SSI with S. aureus (OR 0.57, 95% CI: 0.33-0.99). Overall deep S. aureus SSI decreased significantly from 0.22/100 surgeries to 0.00/100 surgeries in patients adherent to protocol (IRR 0.00, 95% CI 0.00-.85). CONCLUSION:Universal decolonization with Polyhexanide did not reduce overall surgical site infections, but was effective in reducing Staphylococcus aureus - surgical site infections following elective joint arthroplasty. Polyhexanide could extend the list of alternatives to already established decolonization strategies. TRIAL REGISTRATION:The trial was registered at the German Registry for clinical studies www.drks.de ( DRKS00011505 ).

Dataset Information

The dental infections in patients undergoing preoperative dental examination before surgical treatment of saccular intracranial aneurysm.

Publications

The dental infections in patients undergoing preoperative dental examination before surgical treatment of saccular intracranial aneurysm.

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