Ontology highlight
ABSTRACT:
SUBMITTER: Leroux LP
PROVIDER: S-EPMC6105892 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Leroux Louis-Philippe LP Lorent Julie J Graber Tyson E TE Chaparro Visnu V Masvidal Laia L Aguirre Maria M Fonseca Bruno D BD van Kempen Léon C LC Alain Tommy T Larsson Ola O Jaramillo Maritza M
Infection and immunity 20180822 9
The intracellular parasite <i>Toxoplasma gondii</i> promotes infection by targeting multiple host cell processes; however, whether it modulates mRNA translation is currently unknown. Here, we show that infection of primary murine macrophages with type I or II <i>T. gondii</i> strains causes a profound perturbation of the host cell translatome. Notably, translation of transcripts encoding proteins involved in metabolic activity and components of the translation machinery was activated upon infect ...[more]