Ontology highlight
ABSTRACT:
SUBMITTER: Liao YW
PROVIDER: S-EPMC6111815 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Liao Yi-Wen YW Yu Cheng-Chia CC Hsieh Pei-Ling PL Chang Yu-Chao YC
Journal of cellular and molecular medicine 20180612 9
Oral submucous fibrosis (OSF) is a progressive scarring disease. MicroRNA-200b (miR-200b) has been reported as a tumour suppressor, but its role in the precancerous OSF remains unknown. In this study, we investigated the impact of miR-200b on myofibroblastic differentiation activity. Arecoline is a major areca nut alkaloid and has been employed to induce the elevated myofibroblast activity in human buccal mucosal fibroblasts (BMFs). Treatment of arecoline in BMFs dose-dependently reduced gene ex ...[more]