Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6113314 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Zhang Yu Y Zhou Hang H Tao Yongjun Y Liu Xingyu X Yuan Zhu Z Nie Chunlai C
Cell death & disease 20180828 9
The expression of IκB kinase β (IKKβ) promotes the growth of breast cancer cells. Meanwhile, IKKβ mediates the phosphorylation and subsequent degradation of arrest-defective protein 1 (ARD1). However, the relationship between IKKβ and ARD1 in the occurrence of breast cancer has not been reported. In this study, we found that IKKβ not only acts directly on mammalian target of rapamycin (mTOR) activity but also indirectly acts on mTOR activity through posttranscriptional modification of ARD1, ther ...[more]