The comparison of early healing 1-month after PCI among CoCr-everolimus-eluting stent (EES), biodegradable polymer (BP)-EES and BP-sirolimus-eluting stent: Insights from OFDI and coronary angioscopy.

ABSTRACT: Third-generation stents with abluminal biodegradable polymer (BP) might facilitate early healing. Therefore, we compared early healing between second-generation and third-generation stents using coronary angioscopy (CAS) and optical frequency domain imaging [OFDI].We prospectively enrolled 30 consecutive patients with stent implantation for acute coronary syndrome (cobalt?chromium [CoCr] everolimus-eluting stent [EES] [n?=?10], BP-EES [n?=?10], and BP-sirolimus eluting stent [SES] [n?=?10]). All patients underwent CAS and OFDI 1?month after initial percutaneous coronary intervention. On OFDI, the stent coverage (SC), thrombus, and peri-strut low intensity area (PLIA) were assessed. CAS findings were recorded for the grade of SC, grade of yellow color (YC), and grade of the thrombus (TG).On OFDI, the incidences of any thrombus at the 1-month follow-up were 70%, 80%, and 80% in the CoCr-EES, BP-EES, and BP-SES groups, respectively. The percentage of coverage was comparable among the groups (CoCr-EES 79.8 vs. BP-EES 79.9 vs. BP-SES 80.1%, P?=?0.96). However, the number of struts with PLIA was numerically higher in the BP-SES group than in the CoCr-EES and BP-EES groups (46.4?±?25.1 vs. 21.6?±?13.2 vs. 22.0?±?7.2%, P?=?0.08). In the CoCr-EES, BP-EES, and BP-SES groups, mean grades of SC were 1.25?±?0.5, 1.25?±?0.5, and 0.85?±?0.70 (P?=?0.60); mean grades of YC were 0.75?±?0.5, 0.80?±?0.45, and 0.88?±?0.37 (P?=?0.65), and mean grades of TG were 1.00?±?1.00, 1.20?±?0.83, and 0.88?±?0.64 (P?=?0.75), respectively.Third-generation stents are not inferior to second-generation stents regarding stent coverage. However, PLIA on OFDI was often observed with BP-SESs, indicating involvement of the fibrin component.

SUBMITTER: Sato T 

PROVIDER: S-EPMC6113672 | biostudies-other | 2018 Sep

REPOSITORIES: biostudies-other