Ontology highlight
ABSTRACT:
SUBMITTER: Simon T
PROVIDER: S-EPMC6117885 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Simon Thomas T Pinioti Sotiria S Schellenberger Pascale P Rajeeve Vinothini V Wendler Franz F Cutillas Pedro R PR King Alice A Stebbing Justin J Giamas Georgios G
Molecular cancer 20180831 1
Glioblastoma (GBM) is the most aggressive type of primary brain tumours. Anti-angiogenic therapies (AAT), such as bevacizumab, have been developed to target the tumour blood supply. However, GBM presents mechanisms of escape from AAT activity, including a speculated direct effect of AAT on GBM cells. Furthermore, bevacizumab can alter the intercellular communication of GBM cells with their direct microenvironment. Extracellular vesicles (EVs) have been recently described as main acts in the GBM ...[more]