Unknown

Dataset Information

0

Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear ?5-GABAA receptors.


ABSTRACT: Dendrite-targeting GABAergic interneurons powerfully control postsynaptic integration, synaptic plasticity, and learning. However, the mechanisms underlying the efficient GABAergic control of dendritic electrogenesis are not well understood. Using subtype-selective blockers for GABAA receptors, we show that dendrite-targeting somatostatin interneurons and NO-synthase-positive neurogliaform cells preferentially activate ?5-subunit- containing GABAA receptors (?5-GABAARs), generating slow inhibitory postsynaptic currents (IPSCs) in hippocampal CA1 pyramidal cells. By contrast, only negligible contribution of these receptors could be found in perisomatic IPSCs, generated by fast-spiking parvalbumin interneurons. Remarkably, ?5-GABAAR-mediated IPSCs were strongly outward-rectifying generating 4-fold larger conductances above -50?mV than at rest. Experiments and modeling show that synaptic activation of these receptors can very effectively control voltage-dependent NMDA-receptor activation as well as Schaffer-collateral evoked burst firing in pyramidal cells. Taken together, nonlinear-rectifying ?5-GABAARs with slow kinetics match functional NMDA-receptor properties and thereby mediate powerful control of dendritic postsynaptic integration and action potential firing by dendrite-targeting interneurons.

SUBMITTER: Schulz JM 

PROVIDER: S-EPMC6120902 | biostudies-other | 2018 Sep

REPOSITORIES: biostudies-other

altmetric image

Publications

Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABA<sub>A</sub> receptors.

Schulz Jan M JM   Knoflach Frederic F   Hernandez Maria-Clemencia MC   Bischofberger Josef J  

Nature communications 20180903 1


Dendrite-targeting GABAergic interneurons powerfully control postsynaptic integration, synaptic plasticity, and learning. However, the mechanisms underlying the efficient GABAergic control of dendritic electrogenesis are not well understood. Using subtype-selective blockers for GABA<sub>A</sub> receptors, we show that dendrite-targeting somatostatin interneurons and NO-synthase-positive neurogliaform cells preferentially activate α5-subunit- containing GABA<sub>A</sub> receptors (α5-GABA<sub>A</  ...[more]

Similar Datasets

| S-EPMC4373385 | biostudies-literature
| S-EPMC4854965 | biostudies-literature
| S-EPMC6226614 | biostudies-literature
| S-EPMC5924706 | biostudies-literature
| S-EPMC5500312 | biostudies-literature
| S-EPMC3615108 | biostudies-literature
| S-EPMC3513525 | biostudies-literature
| S-EPMC8565927 | biostudies-literature
| S-EPMC7073220 | biostudies-literature
| S-EPMC5905667 | biostudies-literature