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Recent advances in understanding the role of FOXO3.

ABSTRACT: The forkhead box O3 (FOXO3, or FKHRL1) protein is a member of the FOXO subclass of transcription factors. FOXO proteins were originally identified as regulators of insulin-related genes; however, they are now established regulators of genes involved in vital biological processes, including substrate metabolism, protein turnover, cell survival, and cell death. FOXO3 is one of the rare genes that have been consistently linked to longevity in in vivo models. This review provides an update of the most recent research pertaining to the role of FOXO3 in (i) the regulation of protein turnover in skeletal muscle, the largest protein pool of the body, and (ii) the genetic basis of longevity. Finally, it examines (iii) the role of microRNAs in the regulation of FOXO3 and its impact on the regulation of the cell cycle.

SUBMITTER: Stefanetti RJ

PROVIDER: S-EPMC6124385 | biostudies-other | 2018

REPOSITORIES: biostudies-other

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Recent advances in understanding the role of FOXO3.

Stefanetti Renae J RJ Voisin Sarah S Russell Aaron A Lamon Séverine S

F1000Research 20180831

The forkhead box O3 (FOXO3, or FKHRL1) protein is a member of the FOXO subclass of transcription factors. FOXO proteins were originally identified as regulators of insulin-related genes; however, they are now established regulators of genes involved in vital biological processes, including substrate metabolism, protein turnover, cell survival, and cell death. <i>FOXO3</i> is one of the rare genes that have been consistently linked to longevity in <i>in vivo</i> models. This review provides an up ...[more]

PMID: 30228872

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Dataset Information

Recent advances in understanding the role of FOXO3.

Publications

Recent advances in understanding the role of FOXO3.

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