Ontology highlight
ABSTRACT:
SUBMITTER: Golombek SK
PROVIDER: S-EPMC6130746 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Golombek Susanne K SK May Jan-Niklas JN Theek Benjamin B Appold Lia L Drude Natascha N Kiessling Fabian F Lammers Twan T
Advanced drug delivery reviews 20180501
The tumor accumulation of nanomedicines relies on the enhanced permeability and retention (EPR) effect. In the last 5-10 years, it has been increasingly recognized that there is a large inter- and intra-individual heterogeneity in EPR-mediated tumor targeting, explaining the heterogeneous outcomes of clinical trials in which nanomedicine formulations have been evaluated. To address this heterogeneity, as in other areas of oncology drug development, we have to move away from a one-size-fits-all t ...[more]