Unknown

Dataset Information

0

IgG subclass responses to excreted-secreted antigens of Plasmodium falciparum in a low-transmission malaria area of the Peruvian Amazon.


ABSTRACT: Malaria in Peru is concentrated in the Amazon region, especially in Loreto, and transmission is focused in rural and peri-urban communities. The government has approved a malaria elimination plan with a community approach and seeks to reduce the risk of transmission through preventive interventions, but asymptomatic and low-parasite-density infections are challenges for disease control and elimination. IgG antibodies play a critical role in combating infection through their ability to reduce parasitaemia and clinical symptoms. In particular, IgG subclasses have important roles in controlling malaria disease and may provide new insight into the development of malaria control strategies and understanding of malaria transmission. Through the use of excreted-secreted antigens from Plasmodium falciparum, were evaluated the responses of the four IgG subclasses in symptomatic and asymptomatic malarial infections.Higher levels of whole IgG were observed in asymptomatic carriers (P?

SUBMITTER: Saavedra-Langer R 

PROVIDER: S-EPMC6131892 | biostudies-other | 2018 Sep

REPOSITORIES: biostudies-other

altmetric image

Publications

IgG subclass responses to excreted-secreted antigens of Plasmodium falciparum in a low-transmission malaria area of the Peruvian Amazon.

Saavedra-Langer Rafael R   Marapara Jorge J   Valle-Campos Andree A   Durand Salomón S   Vásquez-Chasnamote Maria E ME   Silva Hermann H   Pinedo-Cancino Viviana V  

Malaria journal 20180911 1


<h4>Background</h4>Malaria in Peru is concentrated in the Amazon region, especially in Loreto, and transmission is focused in rural and peri-urban communities. The government has approved a malaria elimination plan with a community approach and seeks to reduce the risk of transmission through preventive interventions, but asymptomatic and low-parasite-density infections are challenges for disease control and elimination. IgG antibodies play a critical role in combating infection through their ab  ...[more]

Similar Datasets

| S-EPMC6428712 | biostudies-literature
| S-EPMC9526214 | biostudies-literature
| S-EPMC5513451 | biostudies-literature
| S-EPMC7030819 | biostudies-literature
| S-EPMC8551272 | biostudies-literature
| S-EPMC6276023 | biostudies-literature
| S-EPMC10101074 | biostudies-literature
| S-EPMC3773727 | biostudies-literature
| S-EPMC4402338 | biostudies-literature
| S-EPMC6757379 | biostudies-literature