Ontology highlight
ABSTRACT:
SUBMITTER: Ebrahimi-Nik H
PROVIDER: S-EPMC6132860 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Ebrahimi-Nik Hakimeh H Corwin William L WL Shcheglova Tatiana T Das Mohapatra Alok A Mandoiu Ion I II Srivastava Pramod K PK
Cancer immunology, immunotherapy : CII 20180720 9
Dendritic cells play a critical role in initiating T-cell responses. In spite of this recognition, they have not been used widely as adjuvants, nor is the mechanism of their adjuvanticity fully understood. Here, using a mutated neoepitope of a mouse fibrosarcoma as the antigen, and tumor rejection as the end point, we show that dendritic cells but not macrophages possess superior adjuvanticity. Several types of dendritic cells, such as bone marrow-derived dendritic cells (GM-CSF cultured or FLT3 ...[more]