Ontology highlight
ABSTRACT:
SUBMITTER: Stevens BM
PROVIDER: S-EPMC6135858 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Nature communications 20180912 1
Myelodysplastic syndrome (MDS) is a chronic hematologic disorder that frequently evolves to more aggressive stages and in some cases leads to acute myeloid leukemia (AML). MDS arises from mutations in hematopoietic stem cells (HSCs). Thus, to define optimal therapies, it is essential to understand molecular events driving HSC pathogenesis. In this study, we report that during evolution of MDS, malignant HSCs activate distinct cellular programs that render such cells susceptible to therapeutic in ...[more]