Ontology highlight
ABSTRACT:
SUBMITTER: Conrad R
PROVIDER: S-EPMC6135870 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Conrad Rachel R Stölting Gabriel G Hendriks Johnny J Ruello Giovanna G Kortzak Daniel D Jordan Nadine N Gensch Thomas T Hidalgo Patricia P
iScience 20180816
Calcium entry through Ca<sub>V</sub>1.2 L-type calcium channels regulates cardiac contractility. Here, we study the impact of exocytic and post-endocytic trafficking on cell surface channel abundance in cardiomyocytes. Single-molecule localization and confocal microscopy reveal an intracellular Ca<sub>V</sub>1.2 pool tightly associated with microtubules from the perinuclear region to the cell periphery, and with actin filaments at the cell cortex. Channels newly inserted into the plasma membrane ...[more]