Ontology highlight
ABSTRACT:
SUBMITTER: Johnson L
PROVIDER: S-EPMC6138822 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Johnson Larry L Almeida-da-Silva Cássio Luiz Coutinho CLC Takiya Christina Maeda CM Figliuolo Vanessa V Rocha Gustavo Miranda GM Weissmüller Gilberto G Scharfstein Julio J Coutinho-Silva Robson R Ojcius David M DM
Biomedical journal 20180601 3
<h4>Background</h4>Fusobacterium nucleatum is a Gram-negative anaerobic bacterium associated with periodontal disease. Some oral bacteria, like Porphyromonas gingivalis, evade the host immune response by inhibiting inflammation. On the other hand, F. nucleatum triggers inflammasome activation and release of danger-associated molecular patterns (DAMPs) in infected gingival epithelial cells.<h4>Methods</h4>In this study, we characterized the pro-inflammatory response to F. nucleatum oral infection ...[more]