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Blue light triggered generation of reactive oxygen species from silica coated Gd3Al5O12:Ce3+ nanoparticles loaded with rose Bengal.

ABSTRACT: This data article provide results of the studies conducted to develop a mesoporous silica coated Gd2.98Ce0.02Al5O12 nanoparticles loaded with a photosensitizer dye rose Bengal (RB) system (GAG@mSiO2@RB) capable of producing reactive oxygen species (ROS) upon exposure to blue light. The data reported here is related with Jain et al. (2018) [1]. It contains histogram of particle size distribution, cathodoluminescence (CL), photoluminescence spectra and there spectral overlap with the absorption spectra of RB, a graph showing the loading percentage of RB at different concentrations. Moreover, the data indicating ROS generation evaluated using 1,2-diphenylisobenzofuran (DPBF) assay and the viability of MDA-MB-231 cells upon exposure with different concentration of GAG@mSiO2 nanoparticles, upon exposure with blue light is also included in the data.

SUBMITTER: Jain A

PROVIDER: S-EPMC6138840 | biostudies-other | 2018 Oct

REPOSITORIES: biostudies-other

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Blue light triggered generation of reactive oxygen species from silica coated Gd3Al5O12:Ce3+ nanoparticles loaded with rose Bengal.

Jain Akhil A Koyani Rina R Muñoz Carlos C Sengar Prakhar P Contreras Oscar E OE Juárez Patricia P Hirata Gustavo A GA

Data in brief 20180830

This data article provide results of the studies conducted to develop a mesoporous silica coated Gd2.98Ce0.02Al5O12 nanoparticles loaded with a photosensitizer dye rose Bengal (RB) system (GAG@mSiO2@RB) capable of producing reactive oxygen species (ROS) upon exposure to blue light. The data reported here is related with Jain et al. (2018) [1]. It contains histogram of particle size distribution, cathodoluminescence (CL), photoluminescence sp ...[more]

PMID: 30225317

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Project description:The molecular imaging of in vivo targets allows non-invasive disease diagnosis. Nanoparticles offer a promising platform for molecular imaging because they can deliver large payloads of imaging reagents to the site of disease. Magnetic resonance imaging (MRI) is often preferred for clinical diagnosis because it uses non-ionizing radiation and offers both high spatial resolution and excellent penetration. We have explored the use of plant viruses as the basis of for MRI contrast reagents, specifically Tobacco mosaic virus (TMV), which can assemble to form either stiff rods or spheres. We loaded TMV particles with paramagnetic Gd ions, increasing the ionic relaxivity compared to free Gd ions. The loaded TMV particles were then coated with silica maintaining high relaxivities. Interestingly, we found that when Gd(DOTA) was loaded into the interior channel of TMV and the exterior was coated with silica, the T1 relaxivities increased by three-fold from 10.9 mM-1 s-1 to 29.7 mM-1s-1 at 60 MHz compared to uncoated Gd-loaded TMV. To test the performance of the contrast agents in a biological setting, we focused on interactions with macrophages because the active or passive targeting of immune cells is a popular strategy to investigate the cellular components involved in disease progression associated with inflammation. In vitro assays and phantom MRI experiments indicate efficient targeting and imaging of macrophages, enhanced contrast-to-noise ratio was observed by shape-engineering (SNP > TMV) and silica-coating (Si-TMV/SNP > TMV/SNP). Because plant viruses are in the food chain, antibodies may be prevalent in the population. Therefore we investigated whether the silica-coating could prevent antibody recognition; indeed our data indicate that mineralization can be used as a stealth coating option to reduce clearance. Therefore, we conclude that the silica-coated protein-based contrast agent may provide an interesting candidate material for further investigation for in vivo delineation of disease through macrophage imaging.

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Blue light triggered generation of reactive oxygen species from silica coated Gd3Al5O12:Ce3+ nanoparticles loaded with rose Bengal.

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Blue light triggered generation of reactive oxygen species from silica coated Gd<sub>3</sub>Al<sub>5</sub>O<sub>12</sub>:Ce<sup>3+</sup> nanoparticles loaded with rose Bengal.

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