Ontology highlight
ABSTRACT:
SUBMITTER: Duan C
PROVIDER: S-EPMC6138893 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Duan Chaorui C Huan Qing Q Chen Xiaoshu X Wu Shaohuan S Carey Lucas B LB He Xionglei X Qian Wenfeng W
Genome biology 20180914 1
<h4>Background</h4>Mutation rates vary across the genome. Many trans factors that influence mutation rates have been identified, as have specific sequence motifs at the 1-7-bp scale, but cis elements remain poorly characterized. The lack of understanding regarding why different sequences have different mutation rates hampers our ability to identify positive selection in evolution and to identify driver mutations in tumorigenesis.<h4>Results</h4>Here, we use a combination of synthetic genes and s ...[more]