Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels.
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ABSTRACT:
SUBMITTER: Bandyopadhyay I
PROVIDER: S-EPMC6139889 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
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Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels.
Bandyopadhyay Indrajit I Chowdhury Sandipan Roy SR Visavadiya Nishant P NP Hecht Sidney M SM Khdour Omar M OM
Data in brief 20180831
As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich's ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues. ...[more]
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