Ontology highlight
ABSTRACT:
SUBMITTER: Pressnitz D
PROVIDER: S-EPMC6146909 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Angewandte Chemie (International ed. in English) 20180621 33
Stereoselective methods for the synthesis of tetrahydro-ß-carbolines are of significant interest due to the broad spectrum of biological activity of the target molecules. In the plant kingdom, strictosidine synthases catalyze the C-C coupling through a Pictet-Spengler reaction of tryptamine and secologanin to exclusively form the (S)-configured tetrahydro-ß-carboline (S)-strictosidine. Investigating the biocatalytic Pictet-Spengler reaction of tryptamine with small-molecular-weight aliphatic ald ...[more]