Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC6149825 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Zhang Jun J Meng Lin-Lin LL Wei Jing-Jing JJ Fan Peng P Liu Sha-Sha SS Yuan Wei-Yu WY Zhao You-Xing YX Luo Du-Qiang DQ
Molecules (Basel, Switzerland) 20171124 12
Protein tyrosine phosphatase 1B (PTP1B) is implicated as a negative regulator of insulin receptor (IR) signaling and a potential drug target for the treatment of type II diabetes and other associated metabolic syndromes. Thus, small molecule inhibitors of PTP1B can be considered as an attractive approach for the design of new therapeutic agents of type II diabetes and cancer diseases. In a continuing search for new PTP1B inhibitors, a new tetramic acid possessing a rare pyrrolidinedione skeleton ...[more]