Ontology highlight
ABSTRACT:
SUBMITTER: Lautrette G
PROVIDER: S-EPMC6150454 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Journal of the American Chemical Society 20160630 27
We describe an efficient and mild method for the synthesis of macrocyclic peptides via nitrogen arylation from unprotected precursors. Various electrophiles and lysine-based nucleophiles were investigated and showed high-yielding product formation, even for a macrocyclization scan with 14 variants. We found that nitrogen-linked aryl products were more stable to base and oxidation when compared to thiol arylated species, thereby highlighting the utility of this methodology. Finally, N-aryl macroc ...[more]