Ontology highlight
ABSTRACT:
SUBMITTER: Lagarrigue F
PROVIDER: S-EPMC6156890 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Lagarrigue Frederic F Gingras Alexandre R AR Paul David S DS Valadez Andrew J AJ Cuevas Monica N MN Sun Hao H Lopez-Ramirez Miguel A MA Goult Benjamin T BT Shattil Sanford J SJ Bergmeier Wolfgang W Ginsberg Mark H MH
Blood advances 20180901 18
Activation of platelet glycoprotein IIb-IIIa (GPIIb-IIIa; integrin αIIbβ3) leads to high-affinity fibrinogen binding and platelet aggregation during hemostasis. Whereas GTP-bound Rap1 GTPase promotes talin 1 binding to the β3 cytoplasmic domain to activate platelet GPIIb-IIIa, the Rap1 effector that regulates talin association with β3 in platelets is unknown. Rap1 binding to the talin 1 F0 subdomain was proposed to forge the talin 1-Rap1 link in platelets. Here, we report a talin 1 point mutant ...[more]