Ontology highlight
ABSTRACT:
SUBMITTER: Kimura W
PROVIDER: S-EPMC6157643 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Kimura Wataru W Nakada Yuji Y Sadek Hesham A HA
Journal of applied physiology (Bethesda, Md. : 1985) 20170817 6
The underlying cause of systolic heart failure is the inability of the adult mammalian heart to regenerate damaged myocardium. In contrast, some vertebrate species and immature mammals are capable of full cardiac regeneration following multiple types of injury through cardiomyocyte proliferation. Little is known about what distinguishes proliferative cardiomyocytes from terminally differentiated, nonproliferative cardiomyocytes. Recently, several reports have suggested that oxygen metabolism and ...[more]