Ontology highlight
ABSTRACT:
SUBMITTER: Dong J
PROVIDER: S-EPMC6162842 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Dong Jing J Levine David M DM Buas Matthew F MF Zhang Rui R Onstad Lynn L Fitzgerald Rebecca C RC Corley Douglas A DA Shaheen Nicholas J NJ Lagergren Jesper J Hardie Laura J LJ Reid Brian J BJ Iyer Prasad G PG Risch Harvey A HA Caldas Carlos C Caldas Isabel I Pharoah Paul D PD Liu Geoffrey G Gammon Marilie D MD Chow Wong-Ho WH Bernstein Leslie L Bird Nigel C NC Ye Weimin W Wu Anna H AH Anderson Lesley A LA MacGregor Stuart S Whiteman David C DC Vaughan Thomas L TL Thrift Aaron P AP
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20180315 10
<h4>Background & aims</h4>Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci for esophageal adenocarcinoma (EA) and Barrett's esophagus (BE). However, variants in these loci account for a small fraction of cases of EA and BE. Genetic factors might interact with environmental factors to affect risk of EA and BE. We aimed to identify single nucleotide polymorphisms (SNPs) that may modify the associations of body mass index (BMI), smoking, and gastroesophageal r ...[more]