Who's Driving? Human Cytomegalovirus, Interferon, and NF?B Signaling.
Ontology highlight
ABSTRACT:
SUBMITTER: Goodwin CM
PROVIDER: S-EPMC6163874 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Publications
Who's Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling.
Goodwin Christopher M CM Ciesla Jessica H JH Munger Joshua J
Viruses 20180821 9
As essential components of the host's innate immune response, NFκB and interferon signaling are critical determinants of the outcome of infection. Over the past 25 years, numerous Human Cytomegalovirus (HCMV) genes have been identified that antagonize or modulate the signaling of these pathways. Here we review the biology of the HCMV factors that alter NFκB and interferon signaling, including what is currently known about how these viral genes contribute to infection and persistence, as well as ...[more]
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