Synergistic Integration of Laboratory and Numerical Approaches in Studies of the Biomechanics of Diseased Red Blood Cells.
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ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC6164935 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Publications
Synergistic Integration of Laboratory and Numerical Approaches in Studies of the Biomechanics of Diseased Red Blood Cells.
Li He H Papageorgiou Dimitrios P DP Chang Hung-Yu HY Lu Lu L Yang Jun J Deng Yixiang Y
Biosensors 20180810 3
In red blood cell (RBC) disorders, such as sickle cell disease, hereditary spherocytosis, and diabetes, alterations to the size and shape of RBCs due to either mutations of RBC proteins or changes to the extracellular environment, lead to compromised cell deformability, impaired cell stability, and increased propensity to aggregate. Numerous laboratory approaches have been implemented to elucidate the pathogenesis of RBC disorders. Concurrently, computational RBC models have been developed to si ...[more]
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