Ontology highlight
ABSTRACT:
SUBMITTER: Santos J
PROVIDER: S-EPMC6165130 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Santos Jephesson J Brito Monalisa M Ferreira Rafael R Moura Ana Paula AP Sousa Tatyanna T Batista Tatianne T Mangueira Vivianne V Leite Fagner F Cruz Ryldene R Vieira Giciane G Lira Bruno B Athayde-Filho Petrônio P Souza Helivaldo H Costa Normando N Veras Robson R Barbosa-Filho José Maria JM Magalhães Hemerson H Sobral Marianna M
International journal of molecular sciences 20180901 9
Natural products have an important role as prototypes in the synthesis of new anticancer drugs. Piperine is an alkaloid amide with antitumor activity and significant toxicity. Then, the <i>N</i>-(p-nitrophenyl)acetamide piperinoate (HE-02) was synthesized, and tested for toxicological and antitumor effects. The toxicity was evaluated in vitro (on RAW 264.7 cells and mice erythrocytes) and in vivo (acute toxicity in mice). The Ehrlich ascites carcinoma model was used to evaluate the antitumor act ...[more]