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Lanthanide DO3A-tropone complexes: efficient dual MR/NIR imaging probes in aqueous medium.

ABSTRACT: In this work, we describe a novel DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) based ligand with a chromophoric tropone coordinating sidearm (1). Ln3+ complexes of 1 have one inner sphere water molecule. The r1 relaxivity of Gd1 is similar to that of the commercial Gd-based MRI agents. The neutral O-donor atom of the tropone moiety slows down the water exchange rate by a factor of 3 compared to GdDOTA. In addition, Nd1 and Yb1 complexes exhibit significant NIR emission in aqueous solutions indicating that the tropone unit is an efficient sensitizer for these Ln3+-ions. Therefore, this new ligand is a promising platform for the design of Ln3+ based dual MR/optical imaging probes.

SUBMITTER: Hashami Z

PROVIDER: S-EPMC6166485 | biostudies-other | 2017 Nov

REPOSITORIES: biostudies-other

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Lanthanide DO3A-tropone complexes: efficient dual MR/NIR imaging probes in aqueous medium.

Hashami Zohreh Z Martins Andre F AF Funk Alexander M AM Jordan Veronica Clavijo VC Petoud Stéphane S Eliseeva Svetlana V SV Kovacs Zoltan Z

European journal of inorganic chemistry 20170824 43

In this work, we describe a novel DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) based ligand with a chromophoric tropone coordinating sidearm (1). Ln3+ complexes of 1 have one inner sphere water molecule. The r1 relaxivity of Gd1 is similar to that of the commercial Gd-based MRI agents. The neutral O-donor atom of the tropone moiety slows down the water exchange rate by a factor of 3 compared to GdDOTA. In addition, Nd1 and Yb<b ...[more]

PMID: 30288139

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