Dataset Information
Lanthanide DO3A-tropone complexes: efficient dual MR/NIR imaging probes in aqueous medium.
Ontology highlight
ABSTRACT:
SUBMITTER: Hashami Z
PROVIDER: S-EPMC6166485 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Publications
Lanthanide DO3A-tropone complexes: efficient dual MR/NIR imaging probes in aqueous medium.
European journal of inorganic chemistry 20170824 43
In this work, we describe a novel DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) based ligand with a chromophoric tropone coordinating sidearm (<b>1</b>). Ln<sup>3+</sup> complexes of <b>1</b> have one inner sphere water molecule. The r<sub>1</sub> relaxivity of Gd<b>1</b> is similar to that of the commercial Gd-based MRI agents. The neutral O-donor atom of the tropone moiety slows down the water exchange rate by a factor of 3 compared to GdDOTA. In addition, Nd<b>1</b> and Yb<b ...[more]