Ontology highlight
ABSTRACT:
SUBMITTER: Abusleme L
PROVIDER: S-EPMC6171814 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Abusleme Loreto L Diaz Patricia I PI Freeman Alexandra F AF Greenwell-Wild Teresa T Brenchley Laurie L Desai Jigar V JV Ng Weng-Ian WI Holland Steven M SM Lionakis Michail S MS Segre Julia A JA Kong Heidi H HH Moutsopoulos Niki M NM
JCI insight 20180906 17
Studies in patients with genetic defects can provide unique insights regarding the role of specific genes and pathways in humans. Patients with defects in the Th17/IL-17 axis, such as patients harboring loss-of-function STAT3 mutations (autosomal-dominant hyper IgE syndrome; AD-HIES) present with recurrent oral fungal infections. Our studies aimed to comprehensively evaluate consequences of STAT3 deficiency on the oral commensal microbiome. We characterized fungal and bacterial communities in AD ...[more]